3 April 2012
4 - 5pm
Venue: Ground Floor Seminar Room (G010), UniServices House, 70 Symonds Street, Auckland
A Bioengineering research seminar by Dr Stephen Gilbert, MRC Special Training Fellow in Biomedical Informatics, Institute of Membrane and Systems Biology, University of Leeds
Cardiac microanatomy is important in myocardial excitation and myocardial contraction, and detailed 3D images are therefore important in understanding normal function and disease. This is particularly true in the field of computational modelling where detailed images are a prerequisite. DT-MRI of ex vivo hearts is an important method for generating ventricular myocardial geometries, but this approach has limitations and drawbacks, and is not yet well validated.
We are undertaking a detailed quantitative validation of DT-MRI by assessing this against structure tensor (ST) analysis of high-spatial resolution MRI and histology. Preliminary results show that DT-MRI and ST provide very similar maps of myocardial fibre orientation. ST is superior in measuring myolaminar structure where DT-MRI performs poorly.