Los Amigos Study

This study is investigating the role of inflammation in lactose malabsorption, trying to find out if a2 Milk™ is digested better than conventional milk in people who are dairy intolerant.

What is the aim of this study?

We’re investigating the different effects that two milk products have on gut comfort, digestion, metabolism and the gut microbiome in people who are intolerant to dairy.

We're measuring the digestive, metabolic, immune and inflammatory response after two weeks of consuming either conventional or a2 Milk™ products. We want to see if either milk product changes the body's ability to digest lactose.  

Why is this study important?

Lots of people report digestive problems after eating dairy, but not all of these people are intolerant to the lactose in milk. Instead, sensitivity to dairy might be caused by the proteins in milk.

Conventional milk contains an A1 version of a protein called β-casein. In some people, this A1 protein causes inflammation in the small intestine and can contribute to lactose intolerance.

The A2 version of the protein breaks down differently and might not cause symptoms in people who are sensitive to the A1 protein. However, we still don’t know how the different proteins are digested and metabolised, or their effects in people who are sensitive to dairy.

This study will help us understand if prolonged consumption of a2 Milk™ improves lactose absorption and tolerance, and if it improves gut comfort, digestive and immune response compared to conventional milk.

How do I enrol?

Recruitment has now finished, but if you'd like to find out how the study is progressing you can contact the study coordinators, Sarah Mitchell and Aahana Shrewstha, on nutrition.mobility@auckland.ac.nz.

This study is funded through High Value Nutrition to AgResearch and in partnership with the a2 Milk™ Company.