A ground-breaking Auckland study could lead to discoveries about many common diseases such as diabetes, cancer and dementia. The new finding could also illuminate the broader role of the enigmatic mitochondria in human development.
Mitochondria are specialised sub-units of cells often described as the cells’ batteries or generators, as they supply most of the cell’s energy. They’re tiny – about 1000th of a millimetre across – with their own membranes. The more energy-hungry the cell type, the more mitochondria it contains – from several to thousands.
What’s fascinating about them is they have their own DNA, separate from the cell’s DNA in its nucleus. We receive the DNA in our cells’ nuclei – organised into chromosomes - from both parents, but we inherit our mitochondrial DNA from our mothers only. Scientists think mitochondria were originally free-living bacteria.
Mutations in the mitochondrial DNA are relatively common - one in a few thousand people - and are linked to common illnesses as well as a wide range of fatal or progressively debilitating diseases including diabetes, gastrointestinal disorders, heart disease, dementia, deafness, and eye disorders.
Now, a team of Liggins Institute researchers have shown for the first time that human mitochondrial DNA leaves the mitochondria, travels into the host cell nucleus and connects to specific genes.
“We found evidence that mitochondria DNA and nuclear DNA ‘talk to each other’, and these interactions aren’t random,” says lead researcher Dr Justin O’Sullivan, a molecular geneticist at the University of Auckland research institute.
The findings give weight to the idea that mitochondria do much more than supply energy and regulate a cell’s metabolism – the processes that keep it alive.
“We think the connections we detected are part of a feedback system between mitochondria and the cell nucleus that may influence how humans grow and develop throughout life,” says Dr O’Sullivan.
“We know that these connections between mitochondrial and nuclear DNA can influence how the nuclear genes work in yeast, and we speculate that the same occurs in humans.”
Interactions between the two sets of DNA within our cells could be one of the ways the environment influences gene expression, he says.