Discovering dysfunction in lymphatic pumps

Millions of microscopic pumps work in synchrony to clear cellular waste products and maintain fluid balance in the human body. These pumps—specialised contractile vessels and valves—form part of the lymphatic system, which, despite its importance, remains one of the least understood systems in human physiology. When lymphatic function is disrupted, especially after cancer treatment, it can lead to lymphoedema, a chronic and incurable condition marked by progressive tissue swelling, pain, and reduced quality of life. Understanding how this system fails is key to improving outcomes for the growing number of cancer survivors affected by lymphatic disease.

This project will use computational modelling to explore how these tiny lymphatic pumps function and how their failure leads to disease. The student will develop ordinary differential equation (ODE) models of ion channel dynamics, calcium signalling, and contraction in lymphatic muscle cells, and then couple these models with simulations of lymph flow through valves and vessels. The goal is to uncover mechanisms that could inspire new therapeutic strategies for lymphoedema.

We are seeking a motivated Master’s student with an interest in mathematical modelling, optimisation and model calibration, and integrative physiology. This project offers the opportunity to work at the interface of computational science and medicine, developing advanced modelling skills while contributing to research with genuine clinical impact.

• Ordinary differential equations
• Mathematical modelling
• Numerical methods
• Programming

This project is eligible for funding but is subject to eligibility criteria & funding availability.

Page expires: 20 April 2026