Chemical sciences for human health

Advances in chemical science underpin all aspects of modern medicine from disease treatment to sanitation, diagnosis, detection and the understanding of disease mechanism and progression.

PG student working in medicinal chemistry

To ensure healthcare development keeps pace with the many healthcare challenges facing our society, novel chemical science research is vital.

We dedicate our research to making an impact in this area both locally and internationally. Key topics include understanding disease mechanisms, design of novel targeted drugs and therapeutics for their treatment. We also examine the development of new devices and sensors to monitor health and diagnose disease.

Research topics

Cancer

Cancer will affect one in three people during their lifetime. With our study of many different cancers, our researchers are developing new treatment strategies such as small molecule chemotherapeutics, immunotherapies (vaccines), tumour-inhibiting metal complexes, antibody-drug conjugates and protein-protein modulators. 

Infectious disease and antimicrobials

Infectious diseases are caused by organisms such as bacteria, viruses, fungi or parasites. There is a growing concern regarding the emergence of virulent pathogens that are resistant to current treatments. Our staff are working to develop new antimicrobial therapies that combat these drug-resistant pathogens. We also target neglected tropical diseases, tuberculosis and viral infections.

Neurodegenerative and psychiatric conditions

Neurodegenerative diseases such as Parkinson’s and Alzheimer’s have no cure. We investigate the underlying mechanisms of these neurodegenerative conditions to help inform new treatment strategies. We are also working on finding new treatments for psychiatric conditions such as depression, a leading disease burden globally. 

Diabetes and obesity

Diabetes mellitus is a metabolic disorder which, if left untreated, can cause serious long-term complications. Our researchers are developing alternatives to current treatments, which could also assist in weight management.

Target identification and drug discovery

Modern drug discovery is becoming increasingly target-based and hypothesis-driven. We use chemical probes and develop tools to identify new targets (such as proteins) and characterise the properties of drugs that can inform the development of new therapeutic agents for a variety of diseases. Our research includes joint theoretical and experimental approaches to screening drugs and understanding the mechanism of action of enzyme inhibitors.

Natural products

Natural products (secondary metabolites) contain a level of structural and chemical diversity that is unsurpassed by artificial libraries. Our staff are designing new synthetic routes to several complex biologically active natural products from both terrestrial and marine sources, enabling their exploration as new therapeutic agents.

Devices and sensors

Rapid detection and effective monitoring are vital for the effective management and treatment of many diseases. Our researchers study how we can detect biological markers, such as antioxidants and neurotransmitters sensitively and selectively, with the sensing events translated into various readout modes, such as electrical or optical signals. We are also developing new biomarkers for cancer using both peptide and DNA based sensing technology.

Our researchers

Associate Professor Bob Anderson

  • Time-resolved spectrophotometry
  • Radical mechanisms
  • Anticancer prodrugs

Associate Professor David Barker

  • Small molecules for disease treatment - cancer and microbial infections
  • Synthesis of biologically active natural products
  • Synthesis of biosensors for disease detection

Distinguished Professor Dame Margaret Brimble

  • Peptide-based antibiotics and bioactive molecules
  • Adjuvants for vaccines
  • Anticancer agents and antibody-drug conjugates

Professor Ralph Cooney

  • Greener commercial antibacterial agents
  • Controlled release bio-agents
  • Encapsulated bio-agents

Professor Brent Copp

  • Medicinal chemistry of anti-infectives
  • Natural products – isolation, synthesis, structure-activity

Dr Daniel Furkert

  • Natural product synthesis
  • New reaction mechanisms
  • Drug discovery

Professor Christian Hartinger

  • Medicinal inorganic chemistry
  • Supramolecular chemistry
  • Bioanalytical chemistry

Dr Kang Huang

  • Novel antimicrobial target delivery systems

Professor Paul Kilmartin

  • Electrochemical sensors

Dr Ivanhoe Leung

  • Disease mechanisms at the protein level
  • Targeting enzymes to improve treatments and therapies

Associate Professor Duncan McGillivray

  • Nanomaterials
  • Surfaces
  • Biophysical chemistry

Dr Davide Mercadante

  • Molecular simulations of protein dynamics 
  • Atomistic, computational studies of protein-bioactive interactions
  • Development of algorithms for covalent docking

Dr Viji Sarojini

  • Alternative therapeutics against drug-resistant pathogens
  • Receptor targeting in cancer therapy using tumour targeting peptides

Associate Professor Jonathan Sperry

  • Neuropsychiatric drug development
  • Anti-infectives
  • Biologically active natural products

Professor Jadranka Travas-Sejdic

  • Optical and electrochemical biosensors
  • Advanced materials with antimicrobial properties

Professor David Williams

  • Solid-state inorganic materials
  • Surfaces
  • Electrochemical characterisation

Dr Geoff Willmott

  • Mechanics of soft particles
  • Resistive pulse sensing